Musculoskeletal System

Bone, Intervertebral Disc - Degeneration

    Narrative
    Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study. There is extrusion/prolapse of the intervertebral disc dorsally, causing compression of the spinal cord.
    Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). There is degeneration of the nucleus pulposus and extrusion/prolapse of disc material dorsally, causing compression of the spinal cord.
    Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study. There is dorsal extrusion of the intervertebral disc, with compression of the overlying spinal cord.
    Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). There is dorsal extrusion of the intervertebral disc, with compression of the overlying spinal cord.
    Bone, Intervertebral disc - Degeneration in a male B6C3F1/N mouse from a chronic study. In this section of vertebral column, there is degeneration of the nucleus pulposus and extrusion/prolapse of disc material.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC