Musculoskeletal System

Bone, Joint - Inflammation

    Narrative
    Bone, Joint - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. There is a marked inflammatory infiltrate within the periarticular soft tissues and subjacent to the articular space and periosteal bone of the joint.
    Bone, Joint - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). There is a marked inflammatory infiltrate within the periarticular soft tissues and subjacent to the articular space and periosteal bone of the joint.
    Bone, Joint - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. This section of metatarsal joint shows inflammation in the periarticular tissues that extends into the subjacent joint space; marked fibroplasia and bony remodeling are also present.
    Bone, Joint - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). This section of metatarsal joint shows inflammation in the periarticular tissues that extends into the subjacent joint space; marked fibroplasia and bony remodeling are also present.
    Bone, Joint - Inflammation, Chronic-active in a male B6C3F1/N mouse from a chronic study. There is severe inflammation within the tarsal joint space and surrounding tissues.
    Bone, Joint - Inflammation, Chronic-active in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 5). This section of the tarsus shows severe inflammation within the joint space and surrounding tissues.
    Bone, Joint - Inflammation, Suppurative in a female Swiss CD-1 mouse from a chronic study. There is marked suppurative inflammation, extensive fibroplasia, and bony remodeling in the paw and digits.
    Bone, Joint - Inflammation, Suppurative in a female Swiss CD-1 mouse from a chronic study (higher magnification of Figure 7). This section of paw and digits shows marked suppurative inflammation, extensive fibroplasia, and bony remodeling.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC