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Skeletal Muscle - Cyst

Image of cyst in the skeletal muscle from a female F344/N rat in a chronic study
eletal muscle - Cyst in a female F344/N rat from a chronic study. A thin-walled epithelium-lined cyst is present within skeletal muscle.
Figure 1 of 4
Image of cyst in the skeletal muscle from a female F344/N rat in a chronic study
Skeletal muscle - Cyst in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is a flattened epithelial cyst wall with cross sections of hair within the lumen.
Figure 2 of 4
Image of cyst in the skeletal muscle from a female F344/N rat in a chronic study
Skeletal muscle - Cyst in a female F344/N rat from a chronic study. A thin-walled cyst partially lined by flattened epithelium and containing keratin debris is present.
Figure 3 of 4
Image of cyst in the skeletal muscle from a female F344/N rat in a chronic study
Skeletal muscle - Cyst in a female F344/N rat from a chronic study (higher magnification of Figure 3). There is necrosis of the epithelial lining (arrow) and keratin debris within the lumen of the cyst.
Figure 4 of 4
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comment:

Epithelium-lined cysts can develop in skeletal muscle ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ). Depending upon their size, compression of adjacent myofibers can occur. The cystic structures can be empty or contain variable amounts of keratin, hair fragments, and/or cellular debris. Joints are a common place for cystic lesions to occur; however, synovial cysts are more common in these regions. Synovial cysts are lined with synovial cells, contain fluid, and may communicate with the adjacent joint.

Parasitic cysts are sometimes present within skeletal muscle. While Sarcocystis muris does infect skeletal muscle in rats and mice, it is not common in well-managed rodent colonies and is generally not associated with accompanying inflammation. If accompanying lesions are present, they are primarily degenerative in nature.

recommendation:

While skeletal muscle cysts are often incidental lesions, their presence should be recorded. A severity grade does not need to be assigned. Accompanying myopathic changes do not need to be diagnosed separately unless warranted by severity. The nature of the lining cells, presence and nature of luminal contents, and regional effects on adjacent skeletal muscle fibers should be addressed in the narrative.

references:

Berridge BR, Van Vleet JF, Herman E. 2013. Cardiac, vascular, and skeletal muscle systems. In: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, 3rd ed (Haschek WM, Rousseaux CG, Wallig MA, Bolon B, Ochoa R, Mahler MW, eds). Elsevier, Amsterdam, 1635-1665.

Greaves P. 2007. Musculoskeletal system. In: Histopathology of Preclinical Toxicity Studies, 3rd ed. Elsevier, Oxford, 160-214.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, von Erichsen J, Yoshida T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle, and mesothelium. J Toxicol Pathol 26(3 suppl):1S-26S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25035576

McDonald MM, Hamilton BF. 1990. Bones, joints, and synovia. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman G, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 193-207.

Percy DH, Barthold SW. 2007. Mouse. In: Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell, Ames, IA, 88-89.

Vahle JL, Leininger JR, Long PH, Hall DG, Ernst H. 2013. Bone, muscle, and tooth. In: Toxicologic Pathology: Nonclinical Safety Assessment (Sahota PS, Popp JA, Hardisty JF, Gopinath C, eds). CRC Press, Boca Raton, FL, 561-587.

Yang S-W, Teng H-P, Tarng Y-W, Wong C-Y. 2007. Intramuscular ganglion cyst of the quadriceps muscle: Report of a case. Mid Taiwan J Med 7:193-197.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.