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Skeletal Muscle - Degeneration - Gallery

Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. A central myofiber is swollen and hypereosinophilic(arrows), and afragmented segment of another fiber (arrowhead) demonstrates segmental degeneration.
Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. An enlarged, hypereosinophilic muscle fiber with subtle vacuolation is present in an otherwise normal muscle bundle.
Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. A rounded fiber contains multiple peripheral nuclei, a single internal nucleus, and abundant cytoplasmic vacuoles.
Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. Multiple macrophages and interstitial cells have phagocytized degenerative portions of an enlarged muscle fiber.
Image of degeneration in the skeletal muscle from a male F344/N rat in a chronic study
Skeletal muscle-Degeneration in a male F344/N rat from a chronic study. In this cross section of muscle, several adjacent muscle fibers exhibit multiple features of degeneration;increased sarcolemmal nuclei are indicative of an early regenerative response.
Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. Degeneration is represented by a swollen, hyalinized, and partly fragmented muscle fiber.
Image of degeneration in the skeletal muscle from a male Harlan Sprague-Dawley rat in a subchronic study
Skeletal muscle-Degeneration in a male Harlan Sprague-Dawley rat from a subchronic study. A fragmented and partly hyalinized muscle fiber has lost its striations and is accompanied by early infiltration of macrophages.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.