Skeletal Muscle - Edema




comment:
Edema in skeletal muscle, as in other tissues, is histologically identified by the expansion of interstitial tissue by amorphous to fibrillar, clear to pale eosinophilic material that separates and surrounds individual myofibers ( Figure 1




While edema can occur as a primary lesion ( Figure 1




recommendation:
When intramuscular edema is the sole or primary lesion, it should be diagnosed and graded. In instances where intramuscular edema is a secondary lesion (e.g., to inflammation), it should not be recorded separately unless warranted by severity but should be described within the pathology narrative.references:
Berridge BR, Van Vleet JF, Herman E. 2013. Cardiac, vascular, and skeletal muscle systems. In: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, 3rd ed (Haschek WM, Rousseaux CG, Wallig MA, Bolon B, Ochoa R, Mahler MW, eds). Elsevier, Amsterdam, 1635-1665.
Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, von Erichsen J, Yoshida T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle, and mesothelium. J Toxicol Pathol 26(3 suppl):1S-26S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25035576
Mosier DA. 2007. Vascular disorders and thrombosis. In: Pathologic Basis of Veterinary Disease (McGavin MD, Zachary JF, eds). Mosby Elsevier, St Louis, 63-100.
Shimazaki C, Ochiai N, Uchida R, Fuchida S-I, Okano A, Ashihara E, Inaba T, Fujita N, Nakagawa M. 2003. Intramuscular edema as a complication of treatment with imatinib. Leukemia 17:804-805. Full Text: http://www.nature.com/leu/journal/v17/n4/full/2402868a.html
Vahle JL, Leininger JR, Long PH, Hall DG, Ernst H. 2013. Bone, muscle, and tooth. In: Toxicologic Pathology: Nonclinical Safety Assessment (Sahota PS, Popp JA, Hardisty JF, Gopinath C, eds). CRC Press, Boca Raton, FL, 561-587.
Web page last updated on: March 11, 2015