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Skeletal Muscle - Edema

Image of edema in the skeletal muscle from a male F344/N rat in a chronic study
Skeletal muscle - Edema in a male F344/N rat from a chronic study. Muscle fibers and muscle bundles are separated by expanded interstitial spaces filled with pale pink material.
Figure 1 of 5
Image of edema in the skeletal muscle from a male F344/N rat in a chronic study
Skeletal muscle - Edema in a male F344/N rat from a chronic study (higher magnification of Figure 1). There are separated muscle fibers and muscle bundles due to an accumulation of pale pink interstitial material.
Figure 2 of 5
Image of edema in the skeletal muscle from a male F344/N rat in a chronic study
Skeletal muscle - Edema in a male F344/N rat from a chronic study. A longitudinal section of skeletal muscle shows expansion of the interstitial spaces due to an accumulation of poorly stained edema fluid.
Figure 3 of 5
Image of edema in the skeletal muscle from a male F344/N rat in a chronic study
Skeletal muscle - Edema in a male F344/N rat from a chronic study (higher magnification of Figure 3). Interstitial spaces are expanded by poorly stained edema fluid.
Figure 4 of 5
Image of edema in the skeletal muscle from a male B6C3F1/N mouse in a subchronic study
Skeletal muscle - Normal in a male B6C3F1/N mouse from a subchronic study. Expanded interstitial space caused by fixation and/or sectioning artifact.
Figure 5 of 5
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comment:

Edema in skeletal muscle, as in other tissues, is histologically identified by the expansion of interstitial tissue by amorphous to fibrillar, clear to pale eosinophilic material that separates and surrounds individual myofibers ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ). It is important to distinguish interstitial spaces that are expanded due to edema from those created in normal tissue as a result of fixation or sectioning artifact ( Figure 5image opens in a pop-up window ). Separation as a result of artifact lacks the presence of pale eosinophilic fibrillar material between muscle fibers and bundles.

While edema can occur as a primary lesion ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ), it most commonly occurs secondary to necrosis and inflammation; regions of hemorrhage are often accompanied by edema. Intramuscular edema can be seen in association with autoimmune conditions, such as polymyositis and dermatomyositis; mild injuries; infectious myositis; subacute denervation; compartment syndrome; and rhabdomyolysis; it can also be seen as a transient, physiologic finding during and briefly following muscle exercise.

recommendation:

When intramuscular edema is the sole or primary lesion, it should be diagnosed and graded. In instances where intramuscular edema is a secondary lesion (e.g., to inflammation), it should not be recorded separately unless warranted by severity but should be described within the pathology narrative.

references:

Berridge BR, Van Vleet JF, Herman E. 2013. Cardiac, vascular, and skeletal muscle systems. In: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, 3rd ed (Haschek WM, Rousseaux CG, Wallig MA, Bolon B, Ochoa R, Mahler MW, eds). Elsevier, Amsterdam, 1635-1665.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, von Erichsen J, Yoshida T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle, and mesothelium. J Toxicol Pathol 26(3 suppl):1S-26S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25035576

Mosier DA. 2007. Vascular disorders and thrombosis. In: Pathologic Basis of Veterinary Disease (McGavin MD, Zachary JF, eds). Mosby Elsevier, St Louis, 63-100.

Shimazaki C, Ochiai N, Uchida R, Fuchida S-I, Okano A, Ashihara E, Inaba T, Fujita N, Nakagawa M. 2003. Intramuscular edema as a complication of treatment with imatinib. Leukemia 17:804-805.
Full Text: http://www.nature.com/leu/journal/v17/n4/full/2402868a.html

Vahle JL, Leininger JR, Long PH, Hall DG, Ernst H. 2013. Bone, muscle, and tooth. In: Toxicologic Pathology: Nonclinical Safety Assessment (Sahota PS, Popp JA, Hardisty JF, Gopinath C, eds). CRC Press, Boca Raton, FL, 561-587.

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Web page last updated on: March 11, 2015

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.