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    • Skeletal Muscle - Hemorrhage

    Image of hemorrhage in the skeletal muscle from a male F344/N rat in a chronic study
    Skeletal muscle - Hemorrhage in a male F344/N rat from a chronic study. Free erythrocytes are present adjacent to and between muscle bundles.
    Figure 1 of 6
    Image of hemorrhage in the skeletal muscle from a male F344/N rat in a chronic study
    Skeletal muscle - Hemorrhage in a male F344/N rat from a chronic study. Erythrocytes and circulating leukocytes are present surrounding individual muscle fibers.
    Figure 2 of 6
    Image of hemorrhage in the skeletal muscle from a female B6C3F1/N mouse in a chronic study
    Skeletal muscle - Hemorrhage in a female B6C3F1/N mouse from a chronic study. In this longitudinal section, erythrocytes are present between muscle fibers.
    Figure 3 of 6
    Image of hemorrhage in the skeletal muscle from a male F344/N rat in a chronic study
    Skeletal muscle - Hemorrhage in a male F344/N rat from a chronic study. Large lakes of erythrocytes surround a large bundle of muscle fibers, some of which are fragmented.
    Figure 4 of 6
    Image of hemorrhage in the skeletal muscle from a male F344/N rat in a chronic study
    Skeletal muscle - Hemorrhage in a male F344/N rat from a chronic study. Macrophages containing golden-brown pigment are present within a region of chronic hemorrhage.
    Figure 5 of 6
    Image of hemorrhage in the skeletal muscle from a male F344/N rat in a chronic study
    Skeletal muscle - Hemorrhage in a male F344/N rat from a chronic study (higher magnification of Figure 5). There are hemosiderin-laden macrophages within a region of chronic hemorrhage.
    Figure 6 of 6
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    comment:

    Hemorrhage in muscle, as in other tissues, is histologically characterized by the extravascular accumulation of blood, which in the case of skeletal muscle separates and surrounds ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , and Figure 3image opens in a pop-up window ), and in some instances effaces ( Figure 4image opens in a pop-up window ), adjacent muscle fibers. Depending upon the cause and severity of the lesion, myofibers in affected regions may remain relatively unaffected ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , and Figure 3image opens in a pop-up window ) or undergo degenerative and/or necrotic changes ( Figure 4image opens in a pop-up window ). Lesions can range from focal and discrete to extensive and widespread. The presence of hemosiderin-laden macrophages within a region of hemorrhage ( Figure 5image opens in a pop-up window and Figure 6image opens in a pop-up window ) implies some degree of chronicity.

    Intramuscular hemorrhage typically occurs following an insult to the muscle, such as blunt trauma, intramuscular injection (injection site), or inflammation. Primary vascular lesions, such as aneurysms and vasculitis, and abnormalities in platelets or coagulation factors can also result in intramuscular hemorrhage.

    recommendation:

    When present as a primary and significant change, intramuscular hemorrhage should be diagnosed and assigned a severity grade based on the extent of the lesion. The pathologist should thoroughly evaluate the tissue in an attempt to determine the primary cause of the hemorrhage (e.g., primary vascular lesions, evidence of trauma). Secondary myopathic changes do not need to be recorded separately unless warranted by severity but should be described in the pathology narrative.

    references:

    Berridge BR, Van Vleet JF, Herman E. 2013. Cardiac, vascular, and skeletal muscle systems. In: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, 3rd ed (Haschek WM, Rousseaux CG, Wallig MA, Bolon B, Ochoa R, Mahler MW, eds). Elsevier, Amsterdam, 1635-1665.

    Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, von Erichsen J, Yoshida T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle, and mesothelium. J Toxicol Pathol 26(3 suppl):1S-26S.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/25035576

    Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA. 2007. Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicol Pathol 35:928-941.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18098039

    Mosier DA. 2007. Vascular disorders and thrombosis. In: Pathologic Basis of Veterinary Disease (McGavin MD, Zachary JF, eds). Mosby Elsevier, St Louis, 63-100.

    Vahle JL, Leininger JR, Long PH, Hall DG, Ernst H. 2013. Bone, muscle, and tooth. In: Toxicologic Pathology: Nonclinical Safety Assessment (Sahota PS, Popp JA, Hardisty JF, Gopinath C, eds). CRC Press, Boca Raton, FL, 561-587.

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    Web page last updated on: March 11, 2015