Brain - Axonopathy - Gallery
Spinal cord axonopathy in a male F344/N rat from a subchronic study. The arrow in this toluidine blue-stained section indicates the subtle pallor of the dorsal funiculus in which axonopathy is present.
Toluidine blue-stained section in a male F344/N rat from a subchronic study. Note that the axons (arrows) are distended but still surrounded by myelin sheaths.
Section in a male B6C3F1 mouse from a subchronic study. Note that some axons are swollen (arrows) and that the tissue is vacuolated from loss of axons and their myelin sheaths.
In this higher magnification image in a female Sprague-Dawley rat from a chronic study, the swollen and degenerate axons devoid of myelin sheath (arrows) are more apparent. Figure
Section in a female F344/N rat from a subchronic study. The arrow indicates a large swollen axon, and the arrowhead locates the presence of a degenerate macrophage occupying the space of a former axon.
This longitudinal section of nerve in a female B6C3F1 mouse from a subchronic study shows an example of axonal fragmentation referred to as Wallerian-type degeneration (arrow).