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    Image of axonopathy in the spinal cord from a male F344/N rat in a subchronic study
    Spinal cord axonopathy in a male F344/N rat from a subchronic study. The arrow in this toluidine blue-stained section indicates the subtle pallor of the dorsal funiculus in which axonopathy is present.
    Image of axonopathy in the spinal cord from a male F344/N rat in a subchronic study
    Toluidine blue-stained section in a male F344/N rat from a subchronic study. Note that the axons (arrows) are distended but still surrounded by myelin sheaths.
    Image of axonopathy in the spinal cord from a male B6C3F1 mouse in a subchronic study
    Section in a male B6C3F1 mouse from a subchronic study. Note that some axons are swollen (arrows) and that the tissue is vacuolated from loss of axons and their myelin sheaths.
    Image of axonopathy in the nerve from a female Harlan Sprague-Dawley rat in a subchronic study
    In this higher magnification image in a female Sprague-Dawley rat from a chronic study, the swollen and degenerate axons devoid of myelin sheath (arrows) are more apparent. Figure
    Image of axonopathy in the nerve from a female F344/N rat in a subchronic study
    Section in a female F344/N rat from a subchronic study. The arrow indicates a large swollen axon, and the arrowhead locates the presence of a degenerate macrophage occupying the space of a former axon.
    Image of axonopathy in the brain from a male B6C3F1 mouse in a subchronic study
    Axonal spheroids (arrows) in brain parenchyma in a male B6C3F1 mouse from a subchronic study.
    Image of axonopathy in the Sciatic nerve from a female B6C3F1 mouse in a subchronic study
    This longitudinal section of nerve in a female B6C3F1 mouse from a subchronic study shows an example of axonal fragmentation referred to as Wallerian-type degeneration (arrow).
    Image of axonopathy in the Sciatic nerve from a male B6C3F1 mouse in a subchronic study
    Increased cellularity created by proliferating Schwann cells (arrows) as a response to axonopathy in a male B6C3F1 mouse from a subchronic study. These linear arrays are known as bands of Büngner.