Brain - Cholesterol Clefts
comment:
A mature degenerate focus is represented in Figure 1
recommendation:
Cholesterol clefts, when present, must be diagnosed in NTP studies and the subsite recorded. In the presence of concurrent lesions, lesions with the most severity are typically diagnosed. Other concurrent lesions may be diagnosed separately, if warranted by the severity.references:
Aflaki E, Radovic B, Chandak PG, Kolb D, Eisenberg T, Ring J, Fertschai I, Uellen A, Wolinski H, Kohlwein SD, Zechner R, Levak-Frank S, Sattler W, Graier WF, Malli R, Madeo F, Kratky D. 2011. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem 286:7418-7428. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21196579
Tabas I. 1997. Free cholesterol-induced cytotoxicity. A possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions. Trends Cardiovasc Med 7:256-263. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21235894
Web page last updated on: June 12, 2014