Brain - Dysplasia

comment:
With the increasing use of generational toxicity studies, recognizing neural dysplasia is becoming increasingly important. Dysplasias include developmental abnormalities in size, organization, and location of various elements of the neural structures. Figure 1

recommendation:
Whenever present in NTP studies, this lesion should be diagnosed and the subsite included in the diagnosis. Severity grading is not required.references:
Colciaghi F, Finardi A, Frasca A, Balosso S, Nobili P, Carriero G, Locatelli D, Vezzani A, Battaglia G. 2011. Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia. Brain 134:2828-2843. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21482549
Kaufmann W, Groters S. 2006. Developmental neuropathology in DNT studies—a sensitive tool for the detection and characterization of developmental neurotoxicants. Reprod Toxicol 22:196-213. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16781841
Park K, Chu K, Jung K, Kim J, Kang K, Lee S, Park H, Kim M, Lee S, Roh J. 2010. Role of cortical dysplasia in epileptogenesis following prolonged febrile seizure. Epilepsia 51:1809-1819. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20738387
Web page last updated on: January 02, 2014