Brain - Intramyelinic Edema



comment:
The presence of “sponginess” ( Figure 4




recommendation:
In NTP studies where intramyelinic edema cannot be differentiated from demyelination or axonopathy under light microscopy, the lesion should be diagnosed as white matter vacuolation. This should be followed by special evaluation by a neuropathologist. In the case of suspected intramyelinic edema, where axonopathy and inflammatory responses are generally absent, examination of only well-fixed material by electron microscopy may be confirmatory. When present in NTP studies, the subsite should be noted and lesion severity graded.references:
Kennedy GL Jr, Dressler IA, Richter WR, Keplinger ML, Calandra JC. 1976. Effects of hexachlorophene in the rat and their reversibility. Toxicol Appl Pharmacol 35:137-145. Abstract: http://www.sciencedirect.com/science/article/pii/0041008X76901198
Purves DC, Garrod IJ, Dayan AD. 1991. A comparison of spongiosis induced in the brain by hexachlorophene, cuprizone and triethyl tin in the Sprague-Dawley rat. Hum Exp Toxicol 10:439-444. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1687857
Tripier MF, Berard M, Toga M, Martin-Bouyer G, Le Breton R, Garat J. 1981. Experimental hexachlorophene encephalopathy in mice and baboons: Light and electron microscopic study. Acta Neuropathol Suppl 7:40-43. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/6939279
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