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    Image of microgliosis in the brain from a female F344/N rat in a chronic study
    Microgliosis adjacent to an inflammatory mononuclear perivascular cuff (arrow) in a female F344/N rat from a chronic study. Note the many elongated, irregular nuclei of typical microglial cells.
    Image of microgliosis in the brain from a female F344/N rat in a chronic study
    Nuclei of microglia at a higher magnification in a female F344/N rat from a chronic study. Their elongated irregular nuclear morphology (arrows) is apparent.
    Image of microgliosis in the brain from an  F344/N rat
    A particularly useful immunohistochemical stain using the Iba-1 antibody to detect these cells (arrows) in the brain in an F344/N rat. Other immunohistochemical methods used as microglial markers include OX-42 and CD68.
    Image of reactive gliosis and capillary hyperplasia in the brain from a female F344/N rat in a chronic study
    Reactive gliosis and capillary hyperplasia (arrow) in a site of former injury in a female F344/N rat from a chronic study. Capillaries are quickly responsive to injury of adjacent tissue, and endothelial nuclear hypertrophy is evident within 24 hours.
    Image of mixed gliosis in the brain from a female B6C3F1 mouse in a chronic study
    A mixed gliotic response to injury of the putamen, consisting of reactive astrocytes, macrophages, microglia, and mononuclear cells, in a male B6C3F1 mouse from a chronic study. It is apparent that there is a significant increase in nucleated cells in the region.
    Image of astrocytosis, gemistocytic in the brain from a female F344/N rat in a chronic study
    Reactive gemistocytic astrocytosis in a site of healing neural injury stained with hematoxylin and eosin, in a treated female F344/N rat from a chronic study. Note the typical eccentric nucleus and prominent eosinophilic cytoplasm of these reactive astrocytes (arrowheads) and the less frequent micro-binucleate form (arrow).