Nervous System

Brain - Mineralization

    Narrative
    Incidental thalamic mineralization in a female F344/N rat from a 16-week study. The arrows identify focal mineral deposits.
    Incidental thalamic mineralization in a male B6C3F1 mouse from a chronic study. Note the irregular shape of the deposits at this high-magnification image.
    A focus of mineral deposition in a site of former cerebellar neuronal necrosis (arrow) in a control male F344/N rat from a subchronic study.
    Higher magnification of a focus of mineralization (calcospherites) at a site of former cerebellar internal granule cell necrosis (arrow) in a male F344/N rat from a subchronic study. Note the concentric lamellar nature of the concretions.
    Brain necrosis with ossification in a male F344/N rat from a chronic study. Note the osteoid (arrow) and osseous metaplasia (arrowhead) in a zone of former brain necrosis.

    Authors 

    Peter Little, DVM, MS, PhD, DACVP
    Neuropathology Consultant
    Experimental Pathology Laboratories, Inc.  
    Research Triangle Park, NC

    Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP
    NTP Pathologist (Contractor)
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    James P. Morrison, DVM, DACVP
    Scientific Director
    Charles River Laboratories, Pathology Associates
    Research Triangle Park, NC

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC