COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Brain - Necrosis - Gallery

Image of necrosis in the brain from an F344/N rat
Appearance of a thalamic infarct at low magnification, identified by pallor within the zone of the black arrows, in an F344/N rat. The dentate gyrus of the hippocampus is identified by a white arrow. This infarct was the result of an arterial embolus (arrowhead), shown at higher magnification in Figure 2.
Image of necrosis in the brain from an F344/N rat
Arterial embolus from Figure 1 at higher magnification, in an F344/N rat.
Image of necrosis in the brain from a male F344/N rat in an acute study
Acute necrosis of the posterior colliculus, a bilaterally symmetrical lesion (arrows), in the whole mount of a section in a male F344/N rat from a 4-day study. This resulted from the selective vulnerability of this brain region to toxin-induced impaired energy metabolism. The arrowhead identifies necrosis of the nucleus of the lateral lemniscus.
Image of necrosis in the brain from a male F344/N rat in an acute study
Similar regionally selective bilateral brain necrosis of the parietal cortex area 1 (blue arrow), thalamus (arrowhead), and retrosplenial cortex (white arrow) in a treated male F344/N rat from a 4-day study, all resulting from the same toxic compound as used in Figure 3.
Image of necrosis in the brain from a female F344/N rat in a chronic study
Unusual form of malacia (total regional necrosis) of the spinal cord in the dorsal spinal funiculi (arrow) in a female F344/N rat from a chronic study.
Image of necrosis in the brain from a male B6C3F1 mouse in a chronic study
A cortical infarct with gliosis and capillary hyperplasia (arrow) from a male B6C3F1 mouse in a chronic study.
Image of necrosis in the brain from a female B6C3F1 mouse in a chronic study
A more advanced stage of cortical infarction (arrows) in a treated female B6C3F1 mouse from a chronic chronic inhalation study.
Image of necrosis in the brain from a F344/N rat in a study
Morphology of an infarct of known duration (arrow) in an F344/N rat with experimental infarction.
Image of necrosis in the brain from a male F344/N rat in a chronic study
Later stage of cortical infarction, with loss of tissue and collapse of the cortical structure creating a depression at the meningeal surface (arrows), in a male F344/N rat from a chronic study.
Image of necrosis in the brain from a F344/N rat in an acute study
Detail of the cellular responses in cortical infarction of known 72-hour duration in an F344/N rat with experimental infarction. Note the hypertrophic and hyperplastic state of the capillary endothelium and the prominent macrophage presence (arrows).
Image of necrosis in the brain from a male B6C3F1 mouse in a chronic study
Olfactory bulb necrosis in a male B6C3F1 mouse from a chronic study. Note that the substance of the olfactory bulb is lost (arrows) as a result of marked tissue necrosis, leaving only cellular debris and hemorrhage.
Image of necrosis in the brain from a female B6C3F1 mouse in a chronic study
Necrotic hippocampal tissue as identified by microtubule-associated protein-2 immunohistochemistry, in a control female B6C3F1 mouse from a chronic study. The arrows demark the region of necrosis.