Nervous System

Brain, Neuron - Degeneration

    Narrative
    Olfactory bulb neuronal degeneration in a female B6C3F1 mouse from a chronic study. The arrow indicates the vacuolation and neuronal degeneration of the olfactory bulb. Gl, glomerular layer; EPl, external plexiform layer; GrO, internal granule cell layer.
    Higher magnification of the internal granule cell layer in the normal olfactory bulb in a female B6C3F1 mouse from a chronic study.
    The contralateral side shows the prominent vacuolation and neuronal degeneration.
    Granulovacuolar neuronal degeneration in a male F344/N rat from an acute study. The black arrowhead indicates neuronal granulovacuolar change, the black arrows identify neurons with central chromatolysis, and the white arrow identifies a genuine basophilic necrotic neuron.
    Granulovacuolar neuronal degeneration in a male F344/N rat from an acute study. Higher magnification of Figure 4. The black arrow indicates neuronal granulovacuolar change, the arrowhead identifies a neuron with central chromatolysis, and the white arrow identifies a genuine basophilic necrotic neuron.

    Authors 

    Peter Little, DVM, MS, PhD, DACVP
    Neuropathology Consultant
    Experimental Pathology Laboratories, Inc.  
    Research Triangle Park, NC

    Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP
    NTP Pathologist (Contractor)
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers

    James P. Morrison, DVM, DACVP
    Scientific Director
    Charles River Laboratories, Pathology Associates
    Research Triangle Park, NC

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC