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    • Brain, Neuron - Necrosis - Gallery

    Image of necrosis in the brain from a male F344/N rat in an acute study
    Neuronal necrosis in a male F344 rat from an acute inhalation study. The black arrow identifies acute eosinophilic necrosis. By contrast, the red arrow identifies a relatively normal neuron, and the arrowhead identifies a pyknotic nucleus amid associated vacuolation of the neuropil.
    Image of necrosis in the brain from a Wistar rat in a subchronic study
    Necrotic neurons as depicted by the Fluoro-Jade technique, in a Wistar rat from a subchronic study. The blue arrow identifies a necrotic neuron, and the white arrow locates the autofluorescence of normal red blood cells in a capillary. Image kindly provided by Dr. G. Krinke. Fluoro-Jade technique.
    Image of necrosis in the brain from a male F344/N rat in a chronic study
    Necrotic piriform cortical neurons in a treated male F344/N rat from a chronic study. The arrows identify necrotic and partially lytic forms of neuronal necrosis.
    Image of necrosis in the brain from a female F344/N rat in a chronic study
    Basophilic neuronal necrosis (arrows) with associated punctate deposits of mineral at the surface from a female F344/N rat in a chronic study.
    Image of necrosis in the brain from a male F344/N rat in a chronic study
    Hippocampal neuronal necrosis (arrows) with more advanced mineralization of the cell bodies, so-called ferrugination of neurons, in a male F344/N rat from a chronic study.
    Image of necrosis in the brain from a female B6C3F1 mouse in an acute study
    Necrosis of internal granule cells at low magnification, in a female B6C3F1 mouse from a 6-week study. Note the shrunken basophilic neurons in contrast to adjacent more normal neurons. The black arrow identifies regions with many necrotic basophilic internal granule cells, whereas the white arrow identifies a region of relative normality.
    Image of necrosis in the brain from a female B6C3F1 mouse in an acute study
    Higher magnification of necrosis of internal granule cells in a female B6C3F1 mouse from a subchronic study. Arrows identify necrotic internal granule cells, whereas arrowheads identify normal internal granule cells.