Nerve - Ectopic Neuron
comment:
Neural dysplasia describes a wide variety of developmental abnormalities, of which abnormal positioning of neurons (heterotopia and ectopia) is frequently a component. Although neuronal ectopia is seldom recognized as a treatment-related effect in general toxicity studies, the advent of generational studies necessitates the recognition of such malformations of neural development. Substantial neuronal ectopias may result from radiation exposure to embryos. Figure 1
recommendation:
Neuronal ectopia should be diagnosed and the subsite area included when possible in NTP studies. Severity grading is not required.references:
Ferrer I, Santamaria J, Alcantera S, Zujar MJ, Cinos C. 1993. Neuronal ectopic masses induced by prenatal irradiation in the rat. Virchows Arch A Pathol Anat Histopathol 422:1-6. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/8438554
Web page last updated on: January 02, 2014