Lung, Alveolar/Bronchiolar Epithelium - Hyperplasia




comment:
Alveolar/bronchiolar epithelial hyperplasia is hyperplasia of the epithelial cells in the centriacinar region (terminal bronchiole/alveolar duct and adjacent alveoli) of the lung ( Figure 1






recommendation:
Lung, Alveolar/bronchiolar epithelium - Hyperplasia should be diagnosed and given a severity grade whenever present. When the hyperplasia is considered secondary to inflammation, it need not be recorded separately unless the pathologist feels that its severity warrants a separate diagnosis. If it is not diagnosed separately, it should be described in the pathology narrative as a component of the inflammatory lesion. If the hyperplastic cells have significant features of atypia, the modifier "atypical" should be included in the diagnosis (i.e., Lung, Alveolar/bronchiolar epithelium - Hyperplasia, Atypical).references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Dixon D, Herbert RA, Sills RC, Boorman GA. 1999. Lungs, pleura, and mediastinum. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 293-332.
Renne, R, Brix A, Harkema J, Herbert R, Kittle B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(suppl):5S-73S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: December 04, 2015