Lung - Atypia, Cellular



comment:
Atypia can be seen in the airways ( Figure 1



recommendation:
Lung - Atypia, Cellular should be diagnosed and assigned a severity grade. A site modifier (e.g., bronchiolar or alveolar epithelium) should be used to indicate which cells are affected. If more than one cell type is affected, the lesion should be diagnosed in all affected sites. If it occurs in areas of epithelial hyperplasia, the term "hyperplasia, atypical" should be used (see Lung, Epithelium, Alveolus - Hyperplasia). If it occurs in an area of squamous metaplasia, the term "metaplasia, squamous, atypical" should be used (see Lung - Metaplasia, Squamous). Since some features of atypia can be seen in regenerating cells, care must be taken not to overdiagnose this lesion. Associated lesions, such as inflammation, should be diagnosed separately.references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Knight JA, Rezuke WN, Gillies CG, Hopfer SM, Sunderman FW. 1988. Pulmonary histopathology of rats following parenteral injections of nickel chloride. Toxicol Pathol 16:350-359. Full Text: http://tpx.sagepub.com/content/16/3/350.full.pdf
Solano-Lopez C, Zeidler-Erdely PC, Hubbs AF, Reynolds SH, Roberts JR, Taylor MD, Young SH, Castranova V, Antonini JM. 2006. Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice. Toxicol Pathol 34:364-372. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16844664
Web page last updated on: December 02, 2015