Respiratory System

Lung, Epithelium - Degeneration

    Narrative
    Lung, Epithelium, Bronchiole - Degeneration in a male B6C3F1/N mouse from a subchronic study. The epithelial cells in this bronchiole are sloughing into the lumen, but there is little inflammation.
    Lung, Epithelium, Bronchiole - Degeneration in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 1). The epithelial cells are vacuolated and sloughing and have lost their cilia, but there is little necrotic debris or inflammation.
    Lung, Epithelium, Bronchiole - Degeneration in a male B6C3F1/N mouse from a subchronic study. The epithelial cells are sloughing into the lumen, and there are occasional pyknotic nuclei, but there is little necrotic debris or inflammation.
    Lung, Epithelium, Bronchiole - Degeneration in a male B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). The epithelial cells are vacuolated and sloughing, but there is little necrotic debris or inflammation.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC