Lung - Foreign Material

Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study. The black material is considered to be the test agent.
Figure 1 of 4

Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The black material is considered to be the test agent, and the majority is contained within alveolar macrophages.
Figure 2 of 4

Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study. The brown to black material within the macrophages is considered to be the test agent.
Figure 3 of 4
comment:
Foreign material ( Figure 1



The response to inhaled test material varies from histiocyte infiltration with relatively inert material to a more severe inflammatory reaction that may be acute (in short-term studies), chronic active, chronic, or granulomatous, depending on the physicochemical properties of the foreign material. Other lesions may be associated with an inflammatory response, such as alveolar proteinosis, necrosis, fibrosis, or epithelial hyperplasia of the airways and/or alveoli.
recommendation:
Lung - Foreign material (inhaled test material or presumed test material) should be diagnosed and graded whenever present. The specific location (e.g., alveolus, bronchus, or bronchiole) should be indicated in the diagnosis as a site modifier. If the foreign material is present in more than one location, the site modifier may be omitted and the locations described in the pathology narrative. Associated lesions (e.g., histiocytic infiltration, inflammation, necrosis, fibrosis, epithelial hyperplasia) should be diagnosed and graded separately.references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Dixon D, Herbert RA, Sills RC, Boorman GA. 1999. Lungs, pleura, and mediastinum. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 293-332.
Renne RA, Dungworth DL, Keenan CM, Morgan KT, Hahn FF, Schwartz LW. 2003. Non-proliferative lesions of the respiratory tract in rats. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC.
Web page last updated on: December 03, 2015