Respiratory System

Lung - Foreign Material

    Narrative
    Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study. The black material is considered to be the test agent.
    Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study (higher magnification of Figure 1). The black material is considered to be the test agent, and the majority is contained within alveolar macrophages.
    Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study. The brown to black material within the macrophages is considered to be the test agent.
    Lung, Alveolus - Foreign material in a male Harlan Sprague-Dawley rat from a subchronic study. The brown to black material associated with the alveolar proteinosis is considered to be the test agent.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC