Respiratory System

Lung - Infiltration Cellular, Histiocyte

    Narrative
    Lung - Infiltration cellular, Histiocyte in a male Wistar Han rat from a subchronic study. There is a small, subpleural accumulation of alveolar histiocytes.
    Lung - Infiltration cellular, Histiocyte in a female Harlan Sprague-Dawley rat from a chronic study. There is a small, subpleural accumulation of alveolar histiocytes with some thickening of associated alveolar septae.
    Lung - Infiltration cellular, Histiocyte in a control male F344/NTac rat from a subchronic study. There is a focal accumulation of histiocytes in several adjacent alveoli.
    Lung - Infiltration cellular, Histiocyte in a control male F344/NTac rat form a subchronic study (higher magnification of Figure 3). Many of the alveolar macrophages in this focal accumulation contain variably sized vacuoles.
    Lung - Infiltration cellular, Histiocyte in a male Wistar Han rat from a subchronic study. These histiocytes contain brown material, which is considered to be the test agent, and this animal would also be diagnosed with foreign material.
    Lung - Infiltration, Cellular, Histiocyte in a male Harlan Sprague-Dawley rat from a subchronic study. These histiocytes contain black material, which is considered to be the test agent; this animal would also be diagnosed with foreign material.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC