Respiratory System

Lung - Inflammation

    Narrative
    Lung - Inflammation, Acute in a male Wistar Han rat from a subchronic study. The majority of the inflammatory cells are neutrophils; there is also a small amount of hemorrhage.
    Lung - Inflammation, Acute in a male Wistar Han rat from a subchronic study (higher magnification of Figure 1). The majority of the inflammatory cells are neutrophils, but there are also mononuclear cells, including alveolar macrophages.
    Lung - Inflammation, Suppurative in a male Wistar Han rat from a chronic study. Large numbers of degenerate neutrophils fill and replace alveoli.
    Lung - Inflammation, Suppurative in a male Wistar Han rat from a chronic study (higher magnification of Figure 3). Abundant necrotic debris is admixed with the degenerate neutrophils.
    Lung, Bronchiole - Inflammation, Suppurative in a male B6C3F1/N mouse from a chronic study. Degenerate neutrophils fill the bronchiole.
    Lung - Inflammation, Suppurative in a female B6C3F1/N mouse from a chronic study. There are numerous large, foamy, activated alveolar macrophages amid the degenerate neutrophils.
    Lung - Inflammation, Chronic in a female B6C3F1/N mouse from a chronic study. The mononuclear inflammatory cells are largely perivascular, peribronchiolar, and subpleural.
    Lung - Inflammation, Chronic in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 7). Mott cells are visible amid the lymphocytes and plasma cells in the subpleural region.
    Lung - Inflammation, Chronic in a male F344/N rat from a subchronic study. These focal, subpleural lesions are a common background finding.
    Lung - Inflammation, Chronic in a male F344/N rat from a subchronic study. This is a slightly more severe example of the common background lesion shown in Figure 9, with thickening of the alveolar septa.
    Lung - Inflammation, Chronic in a female B6C3F1/N mouse from a chronic study. Numerous cholesterol clefts and pigmented macrophages are present in this inflammatory lesion.
    Lung - Inflammation, Chronic in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 11). The macrophages are large, foamy, and activated.
    Lung - Inflammation, Chronic active in a male F344/N rat from a subchronic study. There is a mixture of lymphocytes, macrophages, and neutrophils.
    Lung - Inflammation, Chronic active in a male F344/N rat from a subchronic study (higher magnification of Figure 13). There is a mixture of lymphocytes, macrophages, and neutrophils, with a small amount of alveolar hemorrhage.
    Lung - Inflammation, Chronic active in a male F344/NTac rat from a subchronic study. The perivascular and interstitial inflammation in this control rat is consistent with Pneumocystis carinii infection (formerly rat respiratory virus).
    Lung - Inflammation, Chronic active in a male F344/NTAC rat from a subchronic study (higher magnification of Figure 15). The lesion is consistent with Pneumocystis carinii infection (formerly rat respiratory virus).
    Lung - Inflammation, Chronic active in a male B6C3F1/N mouse from a subchronic study. There is a mixture of inflammatory cell types, including neutrophils, and alveolar proteinosis.
    Lung - Inflammation, Granulomatous in a male Wistar Han rat from a chronic study. Clusters of large, foamy macrophages are surrounded by mononuclear cells.
    Lung - Inflammation, Granulomatous in a female F344/NTAC rat from a subchronic study. There are numerous multinucleated giant cells in this lesion.
    Lung - Inflammation, Granulomatous from a female F344/NTac rat in a subchronic study (higher magnification of Figure 19). The multinucleated giant cells are of the Langhans type.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC