Lung - Metaplasia, Squamous







comment:
Squamous metaplasia of the alveolar epithelium ( Figure 1








recommendation:
Lung - Metaplasia, Squamous should be diagnosed whenever present and assigned a severity grade. A site modifier (i.e., alveolus, bronchiole, or bronchus) should be included in the diagnosis to indicate the location of the lesion. Associated lesions, such as inflammation, fibrosis, necrosis, or hyperplasia, should be diagnosed separately. If atypia is present, then the modifier "atypical" should be added to the diagnosis.references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Renne, R, Brix A, Harkema J, Herbert R, Kittle B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Sells DM, Brix AE, Nyska A, Jokinen MP, Orzech DP, Walker NJ. 2007. Respiratory tract lesions in noninhalation studies. Toxicol Pathol 35:170-177. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433271/
Walker NJ, Yoshizawa K, Miller RA, Brix AE, Sells DM, Jokinen MP, Wyde ME, Easterling M, Nyska A. 2007. Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. Toxicol Pathol 35:880-889.
Web page last updated on: December 03, 2015