Respiratory System

Lung - Proteinosis

    Narrative
    Lung, Alveolus - Proteinosis in a male B6C3F1/N mouse from a chronic study. There is amorphous, brightly eosinophilic material (proteinosis) within the alveoli.
    Lung, Alveolus - Proteinosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Little to no inflammation is associated with the amorphous, brightly eosinophilic material (proteinosis) in the alveoli.
    Lung, Alveolus - Proteinosis in a male B6C3F1 mouse from a subchronic study. There is amorphous, eosinophilic material (proteinosis) within the alveoli.
    Lung, Alveolus - Proteinosis in a male F344/N rat from a subchronic study (higher magnification of Figure 3). Scattered alveolar macrophages are associated with the amorphous, eosinophilic material (proteinosis) in the alveoli.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC