Lung - Proteinosis

Lung, Alveolus - Proteinosis in a male B6C3F1/N mouse from a chronic study. There is amorphous, brightly eosinophilic material (proteinosis) within the alveoli.
Figure 1 of 4

Lung, Alveolus - Proteinosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Little to no inflammation is associated with the amorphous, brightly eosinophilic material (proteinosis) in the alveoli.
Figure 2 of 4

Lung, Alveolus - Proteinosis in a male B6C3F1 mouse from a subchronic study. There is amorphous, eosinophilic material (proteinosis) within the alveoli.
Figure 3 of 4
comment:
Alveolar proteinosis ( Figure 1



recommendation:
Lung - Proteinosis should be diagnosed whenever present and graded based on the extent of the lesion. Since alveolar macrophages are often increased in association with this lesion, they need not be diagnosed separately unless they comprise a significant component of the lesion. Inflammation should be diagnosed separately since it is not typically associated with this lesion. Proteinosis that is secondary to a neoplasm should not be diagnosed but may be described in the pathology narrative.references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Dixon D, Herbert RA, Sills RC, Boorman GA. 1999. Lungs, pleura, and mediastinum. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 293-332.
Hook GER. 1991. Alveolar proteinosis and phospholipodoses of the lungs. Toxicol Pathol 19:482-513. Abstract: http://tpx.sagepub.com/content/19/4-1/482.refs
Web page last updated on: December 03, 2015