Respiratory System

Lung - Regeneration

    Narrative
    Lung, Bronchiole - Regeneration in a male Wistar Han rat from an acute study. A single, thin layer of flattened epithelial cells covers the bronchiolar surface.
    Lung, Bronchiole - Regeneration in a male Wistar Han rat from an acute study. There is a single layer of flattened epithelial cells on the bronchiolar surface; the cell debris (arrow) in the bronchiolar lumen suggests epithelial damage.
    Lung, Bronchiole - Regeneration in a male Wistar Han rat from an acute study. The scattered necrotic cells in the epithelium (arrows) suggest that this hyperplastic response is associated with regeneration secondary to previous damage.

    Authors

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist/NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Darlene Dixon, DVM, PhD, DACVP
    Group Leader
    Molecular Pathogenesis Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Ronald A. Herbert, DVM, PhD
    Group Leader/NTP Pathologist
    Pathology Support Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC


    Lauren M. Staska, DVM, PhD, DACVP
    Senior Pathologist
    WIL Research
    Hillsborough, NC

    Reviewers

    Gary A. Boorman, DVM, PhD, DACVP, DABT, DACLAM
    Pathologist
    Covance Laboratories, Inc.
    Chantilly, VA

    Robert C. Sills, DVM, PhD, FIATP
    Chief, Cellular and Molecular Pathology Branch
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC