Lung - Ulceration

comment:
Ulceration of the bronchial or bronchiolar epithelium represents loss of the lining epithelium ( Figure 1

recommendation:
Lung – Ulceration should be diagnosed and assigned a severity grade whenever present. A site modifier (e.g., bronchus, bronchiole, alveolus) should be included in the diagnosis to indicate the location of the lesion. If the necrotic cells are still attached to the airway surface, then necrosis should be diagnosed; if the adjacent cells have flattened and migrated across the ulcer, then regeneration should be diagnosed (see Lung, Epithelium - Necrosis and Lung - Regeneration). Associated lesions, such as inflammation, should not be diagnosed separately unless warranted by severity but should be described in the pathology narrative.references:
Boorman GA, Eustis SL. 1990. Lung. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 339-367.
Bucher JR, Boorman GA, Gupta BN, Uraih LC, Hall LB, Stefanski SA. 1987. Two-hour methyl isocyanate inhalation exposure and 91-day recovery: A preliminary description of pathologic changes in F344 rats. Environ Health Perspect 72:71-75. Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474667/
Dixon D, Herbert RA, Sills RC, Boorman GA. 1999. Lungs, pleura, and mediastinum. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 293-332.
Web page last updated on: December 07, 2015