Lung - Vacuolization, Cytoplasmic



comment:
Cytoplasmic vacuolization in the lungs is most commonly seen in the airway epithelium of mice ( Figure 1



recommendation:
Lung - Vacuolization, Cytoplasmic should be diagnosed and graded. The site (e.g., bronchus, bronchiole, alveolus) should be specified as part of the diagnosis. If the cytoplasmic vacuolization is a feature of a more severe degenerative or necrotic change, then degeneration or necrosis should be the recorded lesion(see Lung, Epithelium - Necrosis and Lung - Regeneration) and the vacuolization should be described in the narrative. Associated lesions, such as inflammation, should be diagnosed and graded separately.references:
Kumar V, Abbas AK, Fausto N. 2005. Robbins and Cotran Pathologic Basis of Disease, 7th ed. Elsevier Saunders, Philadelphia, 20.
National Toxicology Program. 1991. NTP TOX 5. Toxicity Studies of Cobalt Sulfate Heptahydrate in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NIH Publication No. 91-3124. NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/11946
National Toxicology Program. 2011. NTP TR 564. Toxicology and Carcinogenesis Studies of 1-Bromopropane (CAS No. 106-94-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/34854
Plopper CG, Van Winkle LS, Fanucchi MV, Malburg SR, Nishio SJ, Chang A, Buckpitt AR. 2001. Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location. Am J Respir Cell Mol Biol 24:272-281. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/11245626
Wallig MA. 2002. Morphological manifestation of toxic cell injury. In: Handbook of Toxicologic Pathology (Haschek WM, Rousseaux CG, Wallig MA, eds). Academic Press, San Diego, CA, 39-65.
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