Respiratory System

Nose, Epithelium - Degeneration

    Narrative
    Nose, Olfactory epithelium - Degeneration in a male F344/N rat from a chronic study. Numerous vacuoles are present in the olfactory mucosa.
    Nose, Olfactory epithelium - Degeneration in a female B6C3F1/N mouse from a chronic study. A clear vacuole (arrow), disorganization, and homogeneous cytoplasmic change are present in the mucosa.
    Nose, Respiratory epithelium - Degeneration in a male B6C3F1/N mouse from a chronic study. Cytoplasmic vacuoles are present in the respiratory epithelium lining a turbinate.
    Nose, Respiratory epithelium - Degeneration in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). Cytoplasmic vacuoles are present in the respiratory epithelium.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC