Nose, Epithelium - Hyperplasia - Gallery

Nose, Respiratory epithelium - Normal in a male B6C3F1/N mouse from a subchronic study. The normal respiratory epithelium on the nasal septum is presented for comparison with Figures 2-7.

Nose, Respiratory epithelium - Hyperplasia in a female B6C3F1/N mouse from a chronic study. Minimal thickening and folding of the surface epithelium is present, with some nuclear crowding and pleomorphism.

Nose, Respiratory epithelium - Hyperplasia in a female Harlan Sprague-Dawley rat from a chronic study. The thickened proliferative epithelial surface is arranged in regular folds.

Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study. Proliferation of the epithelial cells resulted in thickening of the epithelium, with folding and invagination into the lamina propria forming pseudoglands. A concretion (arrow) is present within one of the pseudoglands.

Nose, Respiratory epithelium - Hyperplasia in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 4). Infolding or invagination of the hyperplastic epithelium forms pseudoglands. A concretion is present within a pseudogland (arrow).

Nose, Transitional epithelium - Hyperplasia in a male F344/N rat from a chronic study. Numbers of superficial epithelial cells are increased, and a focal downgrowth of basal epithelial cells extends into the lamina propria (arrow). Goblet cells are also increased, which may be better termed �goblet cell metaplasia.�