Nose, Epithelium - Hyperplasia






comment:
Transitional or respiratory epithelial hyperplasia is a relatively common treatment-related change and can also be seen in inflammatory lesions caused by foreign bodies and infectious agents. Hyperplasia is an increase in the number of cells and should not be confused with regeneration, which is replacement of lost or damaged cells. Hyperplasia results in thickening of the epithelium ( Figure 2








recommendation:
Hyperplasia of the transitional or respiratory epithelium should be diagnosed whenever present and assigned a severity grade. The site listed in the diagnosis should reflect the epithelial cell type affected. If a particular cell type can be identified as the proliferating cell (e.g., basal cell or goblet cell), that cell type should be included as a modifier. Since these cells are proliferating, they are often slightly larger (hypertrophy) than nonproliferating respiratory epithelial cells. Hypertrophy should be diagnosed separately only if the pathologist is confident that the enlargement is beyond that expected for proliferating cells. If the epithelial cells appear to be abnormal (e.g., cellular or nuclear pleomorphism, anaplasia, or enlargement) or there is an abnormal or aberrant growth pattern (e.g., disorganization of the cells, dyskeratosis, or increased or abnormal mitotic figures), the term “atypical” should be added as a diagnostic modifier (see Nose, Epithelium - Hyperplasia, Atypical). Regenerating epithelial cells may have some irregularity in their cytologic features and arrangement; care must be taken not to mistake this for atypical hyperplasia.related links:
Nose, Epithelium - Hyperplasia, Atypicalreferences:
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Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.
Monticello TM, Morgan KT, Uraih LC. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568333/
National Toxicology Program. 1990. NTP TR-376. Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/8892
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National Toxicology Program. 2006. NTP TR-526. Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9307
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015