Respiratory System

Nose, Epithelium - Metaplasia, Squamous

    Narrative
    Nose, Respiratory epithelium - Metaplasia, Squamous in a male F344/N rat from a chronic study. The normal respiratory epithelium of the nasal septum has been replaced by squamous epithelium.
    Nose, Respiratory epithelium - Metaplasia, Squamous in a female B6C3F1/N mouse from a chronic study. The nasal mucosa has been replaced by keratinized squamous epithelium. Image provided courtesy of Dr. R. Miller.
    Nose, Respiratory epithelium - Metaplasia, Squamous in a male F344/N rat from a chronic study. A thickened layer of squamous epithelium lines both sides of the nasal septum.
    Nose, Respiratory epithelium - Metaplasia, Squamous in a male F344/N rat from a chronic study. The respiratory epithelium on the turbinate and the transitional epithelium on the tip of the turbinate have been replaced by squamous epithelium.
    Nose, Respiratory epithelium - Metaplasia, Squamous in a female B6C3F1/N mouse from a chronic study. A focal proliferation of squamous cells is present on a nasal turbinate.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC