Nose, Epithelium - Metaplasia, Squamous




comment:
Squamous metaplasia ( Figure 1




recommendation:
Squamous metaplasia of the nasal epithelium should be diagnosed whenever present and assigned a severity grade. The affected epithelium should be included in the diagnosis as site modifier. Other lesions, such as inflammation, should be diagnosed separately when warranted by severity. If present, Bowman’s gland dilation and olfactory nerve atrophy should be described in the narrative, unless the lesion is prominent enough to warrant a separate diagnosis (see Nose, Olfactory Epithelium, Glands - Metaplasia). Keratinization may be a component of squamous metaplasia and need not be diagnosed separately; however, it should be described in the narrative. Metaplastic squamous epithelium may contain features of hyperplasia relative to unaffected squamous epithelium (e.g., thickening, rete peg formation), and these features should also be described in the narrative. If features of atypia are present, it should be should be diagnosed by adding the modifier, "atypical."references:
Boorman GA, Morgan KT, Uraih LC. 1990. Nose, larynx, and trachea. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, eds). Academic Press, San Diego, 315-337.
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.
Monticello TM, Morgan KT, Uraih LC. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568333/
National Toxicology Program. 1990. NTP TR-376. Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/8892
National Toxicology Program. 1990. NTP TR-377. Toxicology and Carcinogenesis Studies of CS2 (94% o-Chlorobenzalmalononitrile, CAS No. 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/8893
National Toxicology Program. 1999. NTP TR-482. Toxicology and Carcinogenesis Studies of Furfuryl Alcohol (CAS No. 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/9766
National Toxicology Program. 1999. NTP TR-490. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS No. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/10170
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015