Nose, Epithelium - Necrosis





comment:
Epithelial necrosis ( Figure 1






recommendation:
Epithelial necrosis should be diagnosed and graded whenever present. The necrotic cells, or remnants thereof, must be present if necrosis is to be diagnosed. If necrotic cells are not present, then ulcer or erosion should be diagnosed. A site modifier (e.g., respiratory, transitional, squamous, or olfactory epithelium, vomeronasal organ, lacrimal duct) should be included in the diagnosis to indicate the location of the lesion. If the lesion is present in more than one location, it should be diagnosed separately for each location in which it is a prominent change. Necrosis may occur in the presence of other olfactory changes and should be diagnosed when present as a distinct, clearly defined entity. Necrotic lesions that are secondary to other lesions, such as inflammation, should not be diagnosed separately unless warranted by severity but should be described in the pathology narrative. Associated lesions, such as inflammatory cell infiltrate, inflammation, turbinate bone necrosis, or hemorrhage, should not be diagnosed separately unless warranted by severity.references:
Boorman GA, Morgan KT, Uraih LC. 1990. Nose, larynx, and trachea. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, eds). Academic Press, San Diego, 315-337.
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.
Monticello TM, Morgan KT, Uraih LC. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568333/
National Toxicology Program. 1994. NTP TR-437. Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CAS No. 77-47-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6018
National Toxicology Program. 1999. NTP TR-490. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS No. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/10170
National Toxicology Program. 2008. NTP TR-552. Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CAS No. 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/29275
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015