Respiratory System

Nose, Epithelium - Necrosis

    Narrative
    Nose, Transitional epithelium - Necrosis in a female B6C3F1/N mouse from a subchronic study. The epithelial lining of a turbinate is necrotic, with evidence of exfoliation of necrotic cells.
    Nose, Transitional epithelium - Necrosis in a female B6C3F1/N mouse from a chronic study. Necrotic epithelium is characterized by prominent pyknosis, with evidence of exfoliation; acute inflammation is also present.
    Nose, Transitional epithelium - Necrosis in a B6C3F1/N mouse from a subchronic study. There is epithelial necrosis and loss of epithelium from the nasal turbinate. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Necrosis in a male F344/N rat from a subchronic study. There is loss of cells in the olfactory epithelium.
    Nose, Olfactory epithelium - Necrosis in a female B6C3F1/N mouse from an acute study. Loss of cells and cell debris is present in the olfactory epithelium. Image provided courtesy of Dr. R. Miller.
    Nose, Olfactory epithelium - Necrosis in a male B6C3F1/N mouse from a subchronic study. Necrosis is present in the olfactory epithelium and turbinate bone (plus inflammation).

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC