Nose, Epithelium - Regeneration
comment:
Regeneration ( Figure 1
recommendation:
Regeneration should be diagnosed whenever present and evidence of necrosis or degeneration is also present. Regeneration should not be graded. To convey the severity of the lesion, either necrosis or degeneration must be diagnosed concurrently and graded (see Nose, Epithelium - Degeneration and Nose, Epithelium - Necrosis). The location of the lesion in the nasal cavity should be indicated in the diagnosis by including as a site modifier the type of epithelium that should be present (e.g., respiratory, olfactory). If the number of epithelial cells exceeds that which would be considered within normal limits, hyperplasia should be diagnosed, regardless of whether it is a direct effect of test article exposure or excessive regeneration, but the pathogenesis of the hyperplasia should be discussed in the pathology narrative. Other associated lesions, such as inflammation, atrophy, or metaplasia, should be diagnosed separately. If the regenerating epithelium exhibits significant features of atypia, based on the pathologist’s judgment, then "atypia, cellular" should be diagnosed and graded.references:
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-289.
Web page last updated on: February 23, 2015