Nose - Foreign Material

Nose - Foreign material in a female F344/NTac rat from an acute study. Free dark brown particulate material is present in the nasal cavity (arrows).
Figure 1 of 5

Nose - Foreign material in a female F344/NTac rat from an acute study (higher magnification of Figure 1). The dark brown particulate material (arrows) is associated with proteinaceous material.
Figure 2 of 5

Nose, Nasopharyngeal duct - Foreign material in a female F344/NTac rat from an acute study. Dark brown particulate material is present at the base of the nasopharyngeal duct (arrow).
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Nose, Nasopharyngeal duct - Foreign material in a female F344/NTac rat from an acute study (higher magnification of Figure 3). The dark brown particulate material is within macrophages.
Figure 4 of 5
comment:
Foreign material ( Figure 1





It is uncommon to see the test agent in the nose. There may be little response to small amounts of inert particles, but more reactive materials may elicit an inflammatory response and changes in the nasal epithelium (e.g., degeneration or necrosis, metaplasia, atrophy).
recommendation:
Foreign material (test material or presumed test material) should be diagnosed and graded whenever present. The specific location (e.g., respiratory or olfactory epithelium, nasopharyngeal duct) should be indicated in the diagnosis as a site modifier. If the foreign material is present in the nasal lumen or in more than one location, the site modifier may be omitted and the locations described in the pathology narrative. Associated lesions (e.g., inflammation, necrosis, fibrosis, epithelial hyperplasia) should be diagnosed and graded separately.references:
Web page last updated on: February 24, 2015