Nose - Hyperplasia, Goblet Cell




comment:
Goblet (mucous) cell hyperplasia ( Figure 1





recommendation:
Goblet cell hyperplasia should be diagnosed whenever it is present and assigned a severity grade. The type of epithelium affected should be indicated in the diagnosis by a site modifier (e.g., respiratory epithelium or transitional epithelium). The goblet cells may be enlarged or hypertrophied, but goblet cell hypertrophy should not be concurrently diagnosed; rather, the hypertrophy should be described in the pathology narrative. Associated lesions, such as inflammation or epithelial hyperplasia, should be diagnosed separately.references:
Boorman GA, Morgan KT, Uraih LC. 1990. Nose, larynx, and trachea. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, eds). Academic Press, San Diego, 315-337.
Harkema JR, Hotchkiss JA, Henderson RF. 1989. Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry. Toxicol Pathol 17:525-535. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/2814228
Harkema JR, Morgan KT, Gross EA, Catalano PJ, Griffith WC. 1994. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part VII: Effects on the Nasal Mucociliary Apparatus. Research Report No. 65. Health Effects Institute, Cambridge, MA. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/7888110
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 259-292.
Monticello TM, Morgan KT, Uraih LC. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249-274. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568333/
National Toxicology Program. 1997. NTP TR-461. Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6066
National Toxicology Program. 1999. NTP TR-490. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS No. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/10170
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Wagner JG, Hotchkiss JA, Harkema JR. 2001. Effects of ozone and endotoxin coexposure on rat airway epithelium: Potentiation of toxicant-induced alterations. Environ Health Perspect 109:591-598. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/11544169
Web page last updated on: February 23, 2015