Respiratory System

Nose - Inflammation

    Narrative
    Nose, Respiratory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study. This lesion is a unilateral, ventral, suppurative inflammatory cell response that contains a foreign body (arrow).
    Nose, Respiratory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study (higher magnification of Figure 1). Splendore-Hoeppli material (arrow) is present in the neutrophilic infiltrate.
    Nose, Respiratory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study. The suppurative inflammation in the ventral nasal cavity is associated with bone necrosis (arrow).
    Nose, Olfactory epithelium - Inflammation, Suppurative in a female F344/N rat from a chronic study. There is a proliferative epithelial reaction to the suppurative inflammation in the ventral nasal cavity.
    Nose, Olfactory epithelium - Inflammation, Suppurative in a female F344/N rat from a chronic study (higher magnification of Figure 4). Epithelial hyperplasia is associated with the suppurative inflammation in the ventral nasal cavity.
    Nose, Olfactory epithelium - Inflammation, Suppurative, and Nose, Respiratory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study. In addition to the suppurative reaction in the nasal cavity, the nasopharyngeal duct is also affected.
    Nose, Olfactory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study. A pronounced epithelial proliferative reaction is present secondary to the suppurative inflammation.
    Nose, Respiratory epithelium - Inflammation, Acute in a male B6C3F1/N mouse from a chronic study. Neutrophils are present within the mucosal epithelium.
    Nose, Olfactory epithelium - Inflammation, Suppurative in a male F344/N rat from a chronic study. This nest of abscesses is a category of suppurative inflammation in which the neutrophilic infiltrates are walled off by connective tissue.
    Nose, Olfactory epithelium - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study. Chronic inflammation characterized by exuberant fibrosis is present in the posterior nasal cavity.
    Nose, Olfactory epithelium - Inflammation, Chronic in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 10). Some inflammatory cells are associated with the fibrosis in the posterior nasal cavity.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC