Nose, Nerve - Atrophy



comment:
The olfactory nerves in the lamina propria are bundles of axons from the olfactory neurons whose cell bodies lie in the olfactory epithelium. These nerves are unmyelinated and traverse openings in the ethmoid bone and terminate at the olfactory bulbs. The lesion is characterized by decreased size and number, or complete loss in severe cases ( Figure 3




recommendation:
Olfactory nerve atrophy should be diagnosed as "Nose, Nerve - Atrophy" whenever present. It should be graded based on the size and number of affected olfactory nerves. Other lesions, including olfactory epithelial atrophy or respiratory metaplasia, should be diagnosed separately. Observation of this lesion should prompt close examination of the olfactory lobe of the brain.related links:
Nose, Olfactory Epithelium – Atrophyreferences:
Boorman GA, Morgan KT, Uraih LC. 1990. Nose, larynx, and trachea. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, eds). Academic Press, San Diego, 315-337.
Herbert RA, Leninger JR. 1999. Nose, larynx, and trachea. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, ed). Cache River Press, Vienna, IL, 293-332.
Islam Z, Amuzie CJ, Harkema JR, Pestka JJ. 2007. Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin A: Kinetics and potentiation by bacterial lipopolysaccharide coexposure. Toxicol Sci 98:526-541. Full Text: http://toxsci.oxfordjournals.org/content/98/2/526.full
Uraih LC, Maronpot RR. 1990. Normal histology of the nasal cavity and application of special techniques. Environ Health Perspect 85:187-208. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568325/
Web page last updated on: February 23, 2015