Respiratory System

Nose, Olfactory Epithelium - Atrophy

    Narrative
    Nose, Olfactory epithelium - Atrophy in a female B6C3F1/N mouse from a chronic study. The olfactory epithelium on the tip of the turbinate is thin due to loss of cells.
    Nose, Olfactory epithelium - Atrophy in a male B6C3F1/N mouse from a chronic study. Focal loss of cells results in thinning of the olfactory epithelium in the dorsal meatus at level II.
    Nose, Olfactory epithelium - Atrophy in a male F344/N rat from a chronic study. The olfactory epithelium is thin in multiple areas (arrows).
    Nose, Olfactory epithelium - Atrophy in a male F344/N rat from a chronic study (higher magnification of Figure 3). The olfactory epithelium is thin (arrows) due to loss of cells.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC