Nose, Olfactory Epithelium - Atrophy
comment:Olfactory epithelial atrophy is a loss of cells from the epithelium, resulting in a thinner and less cellular epithelium ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). The epithelial surface may be covered with cuboidal to columnar nonciliated epithelium. It is often part of a spectrum of changes in the nose that includes inflammation, degeneration or necrosis, and respiratory or squamous metaplasia. In fact, olfactory epithelial atrophy is often the end result of degeneration or necrosis of the olfactory epithelium. The underlying turbinate bone may also be atrophic.
recommendation:Olfactory epithelial atrophy should be diagnosed when a lesion is clearly separate from other olfactory epithelial changes such as degeneration, necrosis, or respiratory epithelial metaplasia. Inflammation, olfactory nerve atrophy, and turbinate atrophy may accompany the epithelial changes and should be diagnosed separately (see Nose - Inflammation; Nose, Nerve - Atrophy; and Nose, Turbinate - Atrophy).
related links:Nose - Inflammation
Nose, Nerve - Atrophy
Nose, Turbinate - Atrophy
Hardisty JF, Garman RH, Harkema JR, Lomax LG, Morgan KT. 1999. Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals. Toxicol Pathol 27:618-627. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/10588541
National Toxicology Program. 1993. NTP TR-431. Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6006
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015