Nose, Olfactory Epithelium - Atrophy



comment:
Olfactory epithelial atrophy is a loss of cells from the epithelium, resulting in a thinner and less cellular epithelium ( Figure 1



recommendation:
Olfactory epithelial atrophy should be diagnosed when a lesion is clearly separate from other olfactory epithelial changes such as degeneration, necrosis, or respiratory epithelial metaplasia. Inflammation, olfactory nerve atrophy, and turbinate atrophy may accompany the epithelial changes and should be diagnosed separately (see Nose - Inflammation; Nose, Nerve - Atrophy; and Nose, Turbinate - Atrophy).references:
Hardisty JF, Garman RH, Harkema JR, Lomax LG, Morgan KT. 1999. Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals. Toxicol Pathol 27:618-627. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/10588541
National Toxicology Program. 1993. NTP TR-431. Toxicology and Carcinogenesis Studies of Benzyl Acetate (CAS No. 140-11-4) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6006
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015