Respiratory System

Nose, Olfactory Epithelium - Hyperplasia, Basal Cell

    Narrative
    Nose, Olfactory epithelium - Hyperplasia, Basal cell in a male F344/N rat from a subchronic study. Proliferation of basal cells is present just above the basement membrane of the olfactory mucosa (arrow).
    Nose, Olfactory epithelium - Hyperplasia, Basal cell in a male F344/N rat from a subchronic study. A focal area of proliferation of basal epithelial cells (arrow) is present in the olfactory mucosa.
    Nose, Olfactory epithelium - Hyperplasia, Basal cell in a female F344/N rat from a chronic study. A continuous band of proliferative basal epithelial cells (arrows) is present above the basement membrane of the olfactory mucosa.
    Nose, Olfactory epithelium - Hyperplasia, Basal cell in a male B6C3F1/N mouse from a chronic study. A localized aggregate of proliferative basal cells (arrows) is present in the olfactory mucosa.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC