Nose, Olfactory Epithelium - Hyperplasia, Basal Cell
comment:Basal cell hyperplasia of the olfactory epithelium is characterized by a proliferation of basal cells along the basement membrane of the olfactory epithelium. The proliferating cells form a distinctly identifiable layer above the basement membrane. The cells are bounded by the basement membrane and do not extend into the subjacent lamina propria (which is a feature of atypical olfactory epithelial hyperplasia - see Nose, Epithelium - Hyperplasia, Atypical). Usually, there are concurrent olfactory epithelial changes, such as degeneration or respiratory metaplasia.
recommendation:Basal cell hyperplasia of the nasal olfactory epithelium should be diagnosed and given a severity grade when the proliferating basal cells do not extend beyond the basement membrane into the lamina propria. If the basal cells extend beyond the basement membrane, atypical hyperplasia should be diagnosed (see Nose, Epithelium - Hyperplasia, Atypical). Associated lesions, such as inflammation or degeneration, should be diagnosed separately.
related links:Nose, Epithelium - Hyperplasia, Atypical
Hardisty JF, Garman RH, Harkema JR, Lomax LG, Morgan KT. 1999. Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals. Toxicol Pathol 27:618-627. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10588541
National Toxicology Program. 2002. NTP TR-504. Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CAS No. 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/14886
National Toxicology Program. 2006. NTP TR-534. Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CAS No. 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/17633
Web page last updated on: February 23, 2015