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Eye, Conjunctiva - Edema

Image of conjunctiva edema in the eye from a female F344/N rat in a chronic study
Eye, Conjunctiva - Edema in a female F344/N rat from a chronic study. There is diffuse swelling of the bulbar conjunctiva (arrows) due to accumulation of fluid; inflammatory cells are also present.
Figure 1 of 3
Image of conjunctiva edema in the eye from a female F344/N rat in a chronic study
Eye, Conjunctiva - Edema in a female F344/N rat from a chronic study (higher magnification of Figure 1). The bulbar conjunctiva is expanded by clear to pale eosinophilic fluid (arrow); inflammatory cells are also present.
Figure 2 of 3
Image of conjunctiva edema in the eye from a female F344/N rat in a chronic study
Eye, Conjunctiva - Edema in a female F344/N rat from a chronic study (higher magnification of Figure 1). There is edema of the bulbar conjunctiva characterized by accumulation of clear to pale eosinophilic fluid and inflammatory cells.
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comment:

Edema of the bulbar conjunctiva ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , and Figure 3image opens in a pop-up window ) is characterized by diffuse swelling due to accumulation of clear to pale eosinophilic fluid. Clinically, conjunctival edema is referred to as chemosis. It is a nonspecific finding secondary to such causes as topical irritants, allergens, trauma, and infectious agents. Inflammatory cells may be present in the edematous areas.

recommendation:

Conjunctival edema should be diagnosed and assigned a severity grade. If located in the bulbar conjunctiva, edema can be diagnosed under the organ/subtopography "eye, conjunctiva." If located in the palpebral conjunctiva, it can be diagnosed under the organ/subtopography of “skin, eyelid.” If secondary to another process (e.g., inflammation), conjunctival edema should not be diagnosed separately (unless warranted by severity) but should be described in the narrative.

references:

Maurer JK, Parker RD. 1996. Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at three hours and recovery/day 35. Toxicol Pathol 24:403-411.
Abstract: http://tpx.sagepub.com/content/24/4/403.short

Maurer JK, Parker RD, Carr GJ. 1998. Ocular irritation: Microscopic changes occurring over time in the rat with surfactants of known irritancy. Toxicol Pathol 26:217-225.
Abstract: http://tpx.sagepub.com/content/26/2/217.short

National Toxicology Program. 1994. NTP TR-437. Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CAS No. 77-47-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/6018