Eye, Cornea - Fibrosis
comment:
Fibrosis of the corneal stroma ( Figure 1

recommendation:
Fibrosis that occurs without, or with only minimal, concurrent inflammation, it should be diagnosed and assigned a severity grade. When corneal fibrosis is considered secondary to inflammation, it should not be diagnosed separately unless warranted by its severity, though it should be described in the pathology narrative.references:
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Galiacy SD, Fournié P, Massoudi D, Ancèle E, Quintyn JC, Erraud A, Raymond-Letron I, Rolling F, Malecaze F. 2011. Matrix metalloproteinase 14 overexpression reduces corneal scarring. Gene Ther 18:462-468. Abstract: http://www.nature.com/gt/journal/v18/n5/full/gt2010159a.html
Geiss V, Yoshitomi K. 1991. Eyes. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 471-489. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
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National Toxicology Program. 1989. NTP TR-342. Toxicology and Carcinogenesis Studies of Dichlorvos (CAS No. 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/10790
West-Mays JA. 2006. The keratocyte: Corneal stromal cell with variable repair phenotypes. Int J Biochem Cell Biol 38:1625-1631. Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505273/
Wilson SE. 2012. Corneal myofibroblast biology and pathobiology: Generation, persistence, and transparency. Exp Eye Res 99:78-88. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22542905
Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
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