Eye, Cornea - Metaplasia, Goblet Cell

comment:
Goblet cells are normally present in the conjunctival epithelium, but when they appear in the corneal epithelium, it is recognized as a metaplasitic change ( Figure 1

recommendation:
Corneal goblet cell metaplasia should be diagnosed and assigned a severity grade whenever present. It is generally reactive and secondary to other pathologic processes, but it’s unusual nature necessitates its diagnosis. When present, inflammation should be diagnosed separately.references:
Geiss V, Yoshitomi K. 1991. Eyes. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 471-489. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Greaves P. 2007. Nervous system and special sense organs. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, San Diego, CA, 861-933. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Joussen AM, Poulaki, V, Mitisiades N, Stechschulte SU, Kirchof B, Dartt DA, Fong G-H, Rudge J, Wiegans SJ, Yancopoulos GD, Adamis AP. 2003. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci 44:117-123. Full Text: https://doi.org/10.1167/iovs.01-1277
Maurer JK, Parker RD. 1996. Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at three hours and recovery/day 35. Toxicol Pathol 24:403-411. Abstract: http://tpx.sagepub.com/content/24/4/403.short
National Toxicology Program. 1992. NTP TR-410. Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7700
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