Eye, Cornea - Metaplasia, Goblet Cell
comment:Goblet cells are normally present in the conjunctival epithelium, but when they appear in the corneal epithelium, it is recognized as a metaplasitic change ( Figure 1 and Figure 2 ). Such so-called conjunctivalization of the corneal epithelium is considered a secondary reactive change, often associated with corneal neovascularization and/or inflammation from various causes.
recommendation:Corneal goblet cell metaplasia should be diagnosed and assigned a severity grade whenever present. It is generally reactive and secondary to other pathologic processes, but it’s unusual nature necessitates its diagnosis. When present, inflammation should be diagnosed separately.
Geiss V, Yoshitomi K. 1991. Eyes. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 471-489. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Greaves P. 2007. Nervous system and special sense organs. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Academic Press, San Diego, CA, 861-933. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Joussen AM, Poulaki, V, Mitisiades N, Stechschulte SU, Kirchof B, Dartt DA, Fong G-H, Rudge J, Wiegans SJ, Yancopoulos GD, Adamis AP. 2003. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci 44:117-123. Full Text: https://doi.org/10.1167/iovs.01-1277
Maurer JK, Parker RD. 1996. Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at three hours and recovery/day 35. Toxicol Pathol 24:403-411. Abstract: http://tpx.sagepub.com/content/24/4/403.short
National Toxicology Program. 1992. NTP TR-410. Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: http://ntp.niehs.nih.gov/go/7700
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