Eye, Cornea - Necrosis

comment:
Necrosis of corneal epithelial cells is characterized by shrunken, hypereosinophilic necrotic cells (suggestive of single-cell necrosis) are scattered through the epithelium ( Figure 1

recommendation:
Corneal necrosis should be diagnosed whenever present and assigned a severity grade. The subtopography of corneal necrosis (epithelium, endothelium, stroma) can be described in the pathology narrative. Associated lesions (e.g., inflammation) should be diagnosed separately.references:
Maurer JK, Parker RD, Carr GJ. 1998. Ocular irritation: Microscopic changes occurring over time in the rat with surfactants of known irritancy. Toxicol Pathol 26:217-225. Abstract: http://tpx.sagepub.com/content/26/2/217.short
Newkirk KM, Chandler HL, Parent AE, Young DC, Colitz CMH, Wilkie DA, Kusewitt DF. 2007. Ultraviolet radiation-induced corneal degeneration in 129 mice. Toxicol Pathol 35:817-824. Full Text: http://tpx.sagepub.com/content/35/6/817.full
National Toxicology Program. 2004. NTP TR-515. Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-butyl Ether (CAS No. 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-butyl Ether In Male NBR Rats (Inhalation Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7724
West-Mays JA. 2006. The keratocyte: Corneal stromal cell with variable repair phenotypes. Int J Biochem Cell Biol 38:1625-1631. Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505273/
Web page last updated on: October 24, 2014