Eye, Cornea - Vacuolation, Cytoplasmic


comment:
Corneal epithelial vacuoles ( Figure 1







recommendation:
If occurring as a primary toxic or heritable effect, corneal cytoplasmic vacuolation should be diagnosed and assigned a severity grade. An appropriate site modifier (e.g., epithelium, endothelium, stroma) should be included in the diagnosis to indicate the location of the affected cells. When occurring as a feature or sequela to another pathologic process (e.g., inflammation), corneal cytoplasmic vacuolation should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative.references:
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Guillet R, Wyatt J, Baggs RB, Kellogg CK. 1988. Anesthetic-induced corneal lesions in developmentally sensitive rats. Invest Ophthalmol Vis Sci 29:949-954. Abstract: https://pubmed.ncbi.nlm.nih.gov/3372167/
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National Toxicology Program. 1994. NTP TR-435. Toxicology and Carcinogenesis Studies of 4,4’-Thiobis(6-t-butyl-m-cresol) (CAS No. 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6014
National Toxicology Program. 2012. NTP TR-572. Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CAS No. 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/36154
Smith RS, Sundberg JP, John SWM. 2002. The anterior segment. In: Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods (Smith RS, John SWM, Nishina PM, Sundberg JP, eds). CRC Press, Boca Raton, FL, 111-159.
Yoshida M, Ikadai H, Maekawa, Takahashi M, Nagase S. 1996. Pathological characteristics of mucopolysaccharidosis VI in the rat. J Comp Path 109:141-155. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/8245230
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