Special Senses System

Eye - Inflammation

    Narrative
    Eye, Cornea - Inflammation, Chronic active in a male F344/N rat from a chronic study. There are diffuse stromal inflammatory cell infiltrates (asterisk), stromal neovascularization (arrow), and fibrosis, and concurrent epithelial hyperplasia (arrowhead).
    Eye, Cornea - Inflammation, Chronic active in a female B6C3F1 mouse from a chronic study. There is a focal accumulation of neutrophils and necrotic debris (arrow) within the concurrently hyperplastic epithelium (arrowhead); neovascularization and fibrosis are evident in the underlying stroma (asterisk).
    Eye, Cornea - Inflammation, Suppurative in a male F344/N rat from a subchronic study. There are neutrophils, necrotic debris (asterisk and large clusters of bacteria (arrow) in the cornea.
    Eye, Cornea - Inflammation, Suppurative in a male F344/N rat from a subchronic study. Higher magnification of Figure 3. Suppurative corneal inflammation characterized by neutrophil infiltrates, necrotic debris (asterisk) and large clusters of bacteria (arrow).
    Eye, Anterior chamber - Inflammation, Acute in a male F344/N rat from a chronic study. Abundant inflammatory cells are present in the anterior chamber (arrow), as well as the adjacent corneal stroma (arrowhead).
    Eye, Anterior chamber - Inflammation, Acute in a male F344/N rat from a chronic study (higher magnification of Figure 1). The inflammatory cells in the anterior chamber are almost entirely neutrophils (asterisk).
    Eye, Iris - Inflammation, Acute and Eye, Ciliary body - Inflammation, Acute in a male F344/N rat from a chronic study. There are abundant inflammatory cells in the iris and ciliary body; inflammatory cells are also present in the anterior chamber (A), posterior chamber (P), and cornea (C).
    Eye, Iris - Inflammation, Acute and Eye, Ciliary body - Inflammation, Acute in a male F344/N rat from a chronic study (higher magnification of Figure 1). The inflammatory cells in the iris (arrow) and ciliary body (arrowhead) are neutrophils; those in the anterior chamber (A), posterior chamber (P), and cornea (C) are also neutrophils.
    Eye, Iris - Inflammation, Acute and Eye, Ciliary body - Inflammation, Acute in a male F344/N rat from a chronic study (higher magnification of Figure 1). This higher magnification image shows the neutrophils in the iris and ciliary body in more detail.
    Eye, Choroid - Inflammation, Acute in a female F344/N rat from a chronic study. There are inflammatory cells infiltrating the choroid (arrow) and the retina is detached.
    Eye, Choroid - Inflammation, Acute in a female F344/N rat from a chronic study (higher magnification of Figure 1). There are neutrophils infiltrating the choroid.
    Eye, Vitreous - Inflammation, Acute in a female F344/N rat from a chronic study. There are intravitreal accumulations of inflammatory cells (asterisk).
    Eye, Vitreous - Inflammation, Acute in a female F344/N rat from a chronic study (higher magnification of Figure 1). The intravitreal inflammatory cells are largely neutrophils (asterisk).
    Eye, Retrobulbar - Inflammation, Acute in a female B6C3F1 Mouse from a chronic study. There are numerous inflammatory cells in the retrobulbar space.
    Eye, Retrobulbar - Inflammation, Acute in a female B6C3F1 Mouse from a chronic study. There are numerous neutrophils and macrophages in the retrobulbar space.

    Author

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Ruth E. Hurley, DVM, PHD, DACVP
    Senior Veterinary Pathologist
    Huntingdon Life Sciences
    North Brunswick, NJ

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC