Special Senses System

Eye, Lens - Cataract

    Narrative
    Eye, Lens - Cataract in a female F344/N rat from a chronic study. There are lens fibers with separation, swelling, granularity, condensation, fragmentation, and disruption of the normally orderly configuration.
    Eye, Lens - Cataract in a male F344/N rat from a chronic study. There are swollen, disrupted lens fibers (arrow) with abnormal retention of lens fiber nuclei (arrowhead).
    Eye, Lens - Cataract in a male F344/N rat from a chronic study. There is capsular thickening and wrinkling (arrow), subcapsular anterior epithelial hyperplasia (arrowhead), and swollen, disrupted lens fibers (asterisk).
    Eye, Lens - Cataract in a female F344/N rat from a chronic study. There is subcapsular mineralization (long arrow) of the lens; posterior synechia of the iris (short arrow) is also present.
    Eye, Lens - Cataract in a male F344/N rat from a chronic study. Anterior subcapsular fibrosis (arrow) is intermixed with dark eosinophilic, fragmented lens fiber material (asterisk).
    Eye, Lens - Cataract in a male F344/N rat from a subchronic study. There is hyperplasia (arrowhead) and posterior migration (behind the lens bow) (arrow) of the anterior lens epithelium; there is also retinal degeneration and detachment (R).

    Author

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Ruth E. Hurley, DVM, PHD, DACVP
    Senior Veterinary Pathologist
    Huntingdon Life Sciences
    North Brunswick, NJ

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC