Eye, Optic Nerve - Gliosis


comment:
Glial cell proliferation and/or activation (gliosis) in the optic nerve usually occurs as a reactive change associated with optic nerve degeneration. It has various causes, such as trauma or increased intraocular pressure, and is characterized by focal to diffuse increases in the numbers of glial cells ( Figure 1


recommendation:
Optic nerve gliosis should be diagnosed and assigned a severity grade. The presence of optic nerve gliosis should prompt careful examination of the retina (especially the ganglion cell and nerve fiber layers) for concurrent pathology. Associated lesions, such as optic nerve degeneration, should be diagnosed separately.related links:
Eye, Optic Nerve - Degenerationreferences:
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Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N. 2010. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 58:780-789. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20091782
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Web page last updated on: October 29, 2014