Special Senses System

Eye, Retina - Degeneration

    Narrative
    Eye, Retina - Normal in a male F344/N rat from a chronic study. Normal retina for comparison to Figures 2 and 3.
    Eye, Retina - Degeneration in a male F344/N rat from a chronic study. Mild retinal degeneration, featuring loss of rod and cone photoreceptor processes, single-cell necrosis of outer nuclear layer photoreceptor cells, hypocellularity and disorganization of the inner and outer nuclear layers, and narrowing or absence of the plexiform layers.
    Eye, Retina - Degeneration in a male F344/N rat from a chronic study. Marked retinal degeneration, featuring overall thinning, architectural disruption, loss of almost all cellular elements, and complete absence of the rod and cone photoreceptors and the plexiform layers.

    Author

    Margarita M. Gruebbel, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Ruth E. Hurley, DVM, PHD, DACVP
    Senior Veterinary Pathologist
    Huntingdon Life Sciences
    North Brunswick, NJ

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC