Eye, Retina - Dysplasia

comment:
Retinal dysplasia ( Figure 1

recommendation:
Retinal dysplasia should be diagnosed as present (no severity grade assigned). However, severity grades could be assigned if they would help clarify a treatment effect (especially in perinatal exposure studies).references:
Frame SR, Slone TW. 1966. Nonneoplastic and neoplastic changes in the eye. In: Pathobiology of the Aging Mouse, Vol 2 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 97-103.
Gottschall-Pass KT, Grahn BH, Gorecki DKJ, Paterson PG. 1997. Oscillatory potentials and light microscopic changes demonstrate an interaction between zinc and taurine in the developing rat retina. J Nutr 127:1206-1213. Abstract: http://jn.nutrition.org/content/127/6/1206.full
Haider NB, Naggart JK, Nishina PM. 2001. Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia in rd7/rd7 mice. Hum Mol Gen 10:1619-1626. Full Text: http://hmg.oxfordjournals.org/content/10/16/1619.full
National Toxicology Program. 2012. NTP TR-571. Toxicology and Carcinogenesis Studies of Kava Kava Extract (CAS No. 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/36127
Poulson R, Hayes B. 1988. Congenital retinal folds in Sheffield-Wistar rats. Graefes Arch Clin Exp Ophthalmol 226:31-33. Full Text: https://www.ncbi.nlm.nih.gov/pubmed/3342972
Smith RS, Hawes NL, Chang B, Nishina PM. 2002. Retina. In: Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods (Smith RS, John SWM, Nishina PM, Sundberg JP, eds). CRC Press, Boca Raton, FL, 195-225.
Web page last updated on: October 24, 2014