Eye, Retina - Gliosis

comment:
Retinal gliosis ( Figure 2

recommendation:
When occurring as a primary change, retinal gliosis should be diagnosed and assigned a severity grade. When retinal gliosis occurs as a morphologic feature or reactive sequela of another pathologic process (e.g., retinal degeneration), it should not be diagnosed separately (unless warranted by severity), but should be described in the pathology narrative.references:
Adams ET, Auerbach S, Blackshear PE, Bradley A, Gruebbel MM, Little PB, Malarkey D, Maronpot R, McKay JS, Miller RA, Moore RR, Morrison JP, Nyska A, Ramot Y, Rao D, Suttie A, Wells MY, Willson GA, Elmore SA. 2011. Proceedings of the 2010 National Toxicology Program Satellite Symposium. Toxicol Pathol 39:240-266. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21177527
Brooks DE, Komàromy AM, Källberg ME. 1999. Comparative retinal ganglion cell and optic nerve morphology. Vet Ophthalmol 2:3-11. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/11397238
Ho G, Kumar S, Min XS, Kng YL, Loh MY, Gao S, Zhuo L. 2009. Molecular imaging of retinal gliosis in transgenic mice induced by kainic acid neurotoxicity. Invest Ophthalmol Vis Sci 50:2459-2464. Full Text: https://doi.org/10.1167/iovs.08-2133
Jung HJ, Raine CS, Suzuki K. 1978. Schwann cells and peripheral nervous system myelin in the rat retina. Acta Neuropathol 44:245-247. Abstract: http://link.springer.com/article/10.1007/BF00691075
Langmann T. 2007. Microglia activation in retinal degeneration. J Leukocyte Biol 81:1345-1351. Full Text: http://www.jleukbio.org/content/81/6/1345.full
National Toxicology Program. 2012. NTP TR-571. Toxicology and Carcinogenesis Studies of Kava Kava Extract (CAS No. 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/36127
Seoane A, Espejo M, Pallàs M, Rodriguez-Farre E, Ambrosio S, Llorens J. 1999. Degeneration and gliosis in rat retina and central nervous system following 3,3'-iminodipropionitrile exposure. Brain Res 833:258-271. Full Text: http://toxsci.oxfordjournals.org/content/88/2/456.full.pdf
Yanoff K, Zimmerman LE, Davis R. 1971. Massive gliosis of the retina. Int Ophthalmol Clin 11:211-229.
Yoshitomi K, Boorman GA. 1990. Eye and associated glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, CA, 239-260. Abstract: https://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Zeng H, Zhu X, Zhang C, Yang L-P, Wu L, Tso MOM. 2005. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Invest Ophthalmol Vis Sci 46:2992-2999. Full Text: https://doi.org/10.1167/iovs.05-0118
Web page last updated on: October 29, 2014